CT Imaging and Spontaneous Behavior Analysis After Osmotic Blood-Brain Barrier Opening in Wistar Rat
نویسندگان
چکیده
منابع مشابه
CT imaging and spontaneous behavior analysis after osmotic blood-brain barrier opening in Wistar rat.
In our previous experiments we demonstrated that osmotic opening of the blood brain barrier (BBB) in rats by administration of mannitol into the internal carotid artery leads to cerebral edema. The aim of this study was to confirm objectively the development of brain edema and determine whether it affects spontaneous locomotor activity in rats (SLA). Brain edema was verified by computer tomogra...
متن کاملOsmotic blood-brain barrier disruption: CT and radionuclide imaging.
PURPOSE To compare CT and radionuclide imaging of osmotic blood-brain barrier disruption. To develop a quantitative method for imaging osmotic blood-brain barrier disruption and to see if iopamidol could be safely given intravenously in conjunction with blood-brain barrier disruption. METHODS Forty-five blood-brain barrier disruption procedures were imaged with CT and radionuclide scans. The ...
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Unilateral reversible osmotic opening of the blood-brain barrier can be produced in mice. Infusion of 1.8 molal arabinose in water at a rate of 0.64 ml/min for 30 seconds into the internal carotid artery consistently results in ipsilateral brain staining by intravascular Evans blue dye. Osmotic opening is concentration-dependent (threshold, 1.6 molal arabinose) and reversible within 4 hours. No...
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BACKGROUND AND PURPOSE Reperfusion disrupts cerebral capillaries, causing cerebral edema and hemorrhage. Middle cerebral artery occlusion (MCAO) induces the matrix-degrading metalloproteinases, but their role in capillary injury after reperfusion is unknown. Matrix metalloproteinases (MMPs) and tissue inhibitors to metalloproteinases (TIMPs) modulate capillary permeability. Therefore, we measur...
متن کامل[3H]Methotrexate loss from the rat brain following enhanced uptake by osmotic opening of the blood-brain barrier.
Right brain regions of anesthetized rats were loaded with [3,5,7-3H]methotrexate ([3H]MTX) or with [14C]sucrose by infusing the tracers into the right carotid artery, after the blood-brain barrier had been opened by right carotid infusion of a hypertonic arabinose solution. During the 6 hr following the procedure, the [3H]MTX concentration in 7 right-sided brain regions, when normalized to the ...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2014
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932935